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Effect of RNAi-based β-catenin inhibition on immunosuppressive Wnt-activated tumors in combination with IDOi/PD-1 immunotherapy.

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e15038Background: Wnt/β-catenin pathway activation has been correlated with T-cell exclusion across most human tumors. Additionally, Wnt signaling promotes constitutive IDO1 expression in some tumo... Click to show full abstract

e15038Background: Wnt/β-catenin pathway activation has been correlated with T-cell exclusion across most human tumors. Additionally, Wnt signaling promotes constitutive IDO1 expression in some tumo...

Keywords: effect rnai; catenin inhibition; immunosuppressive wnt; based catenin; rnai based; inhibition immunosuppressive

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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