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Efficacy of pegvorhyaluronidase alfa (PEGPH20) plus FOLFIRINOX in a preclinical model of human pancreatic ductal adenocarcinoma.

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e16244Background: Hyaluronan (HA) accumulates in the solid tumor microenvironment, and is associated with poor drug penetration and negative clinical outcomes. Pegvorhyaluronidase alfa (P) is a nov... Click to show full abstract

e16244Background: Hyaluronan (HA) accumulates in the solid tumor microenvironment, and is associated with poor drug penetration and negative clinical outcomes. Pegvorhyaluronidase alfa (P) is a nov...

Keywords: pegvorhyaluronidase alfa; folfirinox preclinical; efficacy pegvorhyaluronidase; plus folfirinox; pegph20 plus; alfa pegph20

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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