"M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in Asian patients with pretreated recurrent or refractory gastric cancer: Preliminary results from a phase I trial."

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M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in Asian patients with pretreated recurrent or refractory gastric cancer: Preliminary results from a phase I trial.

100Background: Inhibiting the transforming growth factor β (TGF-β) pathway, which plays a key role in tumor immunosuppression, may enhance the response to programmed death 1/programmed death ligand... Click to show full abstract

Keywords: m7824 msb0011359c; protein targeting; targeting tgf; msb0011359c bifunctional; fusion protein; bifunctional fusion

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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