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Association of phosphatidylinositol 3-kinase (PI3K) pathway activation with increased immune checkpoint expression in colorectal cancer (CRC) patients.

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653Background: PI3K pathway is a known modulator of anti-tumor immune response and is frequently activated in CRC through genetic alterations such as PTEN loss (PTENloss) and PIK3CA mutations (PIK3... Click to show full abstract

653Background: PI3K pathway is a known modulator of anti-tumor immune response and is frequently activated in CRC through genetic alterations such as PTEN loss (PTENloss) and PIK3CA mutations (PIK3...

Keywords: pathway activation; kinase pi3k; association phosphatidylinositol; activation increased; phosphatidylinositol kinase; pi3k pathway

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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