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Phase Ib trial of pembrolizumab and XL888 in patients with advanced gastrointestinal malignancies.

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TPS526Background: Heat shock protein 90 (HSP90) has a central role in modulating tumor microenvironment, inflammatory signaling pathways (NF-κB, HIF-1α and Jak-STAT), tumor antigen presentation and... Click to show full abstract

TPS526Background: Heat shock protein 90 (HSP90) has a central role in modulating tumor microenvironment, inflammatory signaling pathways (NF-κB, HIF-1α and Jak-STAT), tumor antigen presentation and...

Keywords: advanced gastrointestinal; xl888 patients; pembrolizumab xl888; patients advanced; trial pembrolizumab; phase trial

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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