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Preliminary safety, efficacy and pharmacokinetics (PK) results of KN026, a HER2 bispecific antibody in patients (pts) with HER2-positive metastatic breast cancer.

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1041Background: KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes, the same domains as trastuzumab (ECD4) and pertuzumab (ECD2). It blocks ligand-dependen... Click to show full abstract

1041Background: KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes, the same domains as trastuzumab (ECD4) and pertuzumab (ECD2). It blocks ligand-dependen...

Keywords: efficacy pharmacokinetics; safety efficacy; antibody; pharmacokinetics results; bispecific antibody; preliminary safety

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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