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Combination of fulvestrant and chemotherapy in ESR1 Y537S mutant breast cancer cells and potential synergy mechanism related to p53 wildtype.

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1065Background: The acquisition of ligand-independent ESR1 mutations during endocrine therapy in metastatic ER+ breast cancer is a common mechanism of resistance to endocrine treatment, particularl... Click to show full abstract

1065Background: The acquisition of ligand-independent ESR1 mutations during endocrine therapy in metastatic ER+ breast cancer is a common mechanism of resistance to endocrine treatment, particularl...

Keywords: combination fulvestrant; mechanism; breast; breast cancer; fulvestrant chemotherapy

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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