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Initial correlative studies from a trial of cetuximab and pembrolizumab in metastatic colorectal cancer (mCRC).

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4062Background: Cetuximab is an EGFR-targeting IgG1 mAb. Pre-clinical data suggests cetuximab induces CD8+ cytotoxic T-cell (CTL) infiltration of tumors. We hypothesized that augmentation of CTLs i... Click to show full abstract

4062Background: Cetuximab is an EGFR-targeting IgG1 mAb. Pre-clinical data suggests cetuximab induces CD8+ cytotoxic T-cell (CTL) infiltration of tumors. We hypothesized that augmentation of CTLs i...

Keywords: cetuximab pembrolizumab; correlative studies; cetuximab; initial correlative; trial cetuximab; studies trial

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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