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Cobimetinib plus gemcitabine is an active combination in KRAS G12R-mutated in previously chemotherapy-treated and failed pancreatic patients.

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4642Background: he KRAS proto-oncogene is involved in the RAS/MAPK pathway. Various G12X mutations have been examined with the most common mutations being G12D (40%), G12V (30%), and G12R (15-20%) ... Click to show full abstract

4642Background: he KRAS proto-oncogene is involved in the RAS/MAPK pathway. Various G12X mutations have been examined with the most common mutations being G12D (40%), G12V (30%), and G12R (15-20%) ...

Keywords: combination kras; cobimetinib plus; active combination; plus gemcitabine; kras g12r; gemcitabine active

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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