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Preclinical evaluation of LX-086, a small molecule as a selective inhibitor of PI3K.

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e15662Background: PI3K/Akt signaling pathway plays a key role in a series of cellular functions related to cell growth, proliferation, survival and differentiation. PI3Kα is ubiquitously expressed,... Click to show full abstract

e15662Background: PI3K/Akt signaling pathway plays a key role in a series of cellular functions related to cell growth, proliferation, survival and differentiation. PI3Kα is ubiquitously expressed,...

Keywords: selective inhibitor; preclinical evaluation; 086 small; molecule selective; small molecule; evaluation 086

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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