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Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients.

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e20547Background: Daratumumab (Dara), an anti-CD38 antibody, has a variety of Fc-dependent immune effector mechanisms of action including macrophage-mediated antibody-dependent cellular phagocytosi... Click to show full abstract

e20547Background: Daratumumab (Dara), an anti-CD38 antibody, has a variety of Fc-dependent immune effector mechanisms of action including macrophage-mediated antibody-dependent cellular phagocytosi...

Keywords: function mechanism; investigating macrophage; macrophage function; macrophage; daratumumab; mechanism resistance

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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