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PT-112 in advanced metastatic castrate-resistant prostate cancer (mCRPC), as monotherapy or in combination with PD-L1 inhibitor avelumab: Findings from two phase I studies.

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83Background: PT-112, the first pyrophosphate conjugate in Phase I/II clinical development, induces robust immunogenic cell death and is osteotropic, prompting study in mCRPC during Phase I. We rep... Click to show full abstract

83Background: PT-112, the first pyrophosphate conjugate in Phase I/II clinical development, induces robust immunogenic cell death and is osteotropic, prompting study in mCRPC during Phase I. We rep...

Keywords: advanced metastatic; phase; metastatic castrate; 112 advanced; castrate resistant; resistant prostate

Journal Title: Journal of Clinical Oncology
Year Published: 2020

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