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Safety and pharmacokinetic analysis of UGT1A1 genotype-guided dosing of irinotecan.

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3574Background: Irinotecan is commonly used in the treatment of advanced colorectal and pancreatic cancer. The polymorphisms UGT1A1*28 (7 TA repeats) and UGT1A1*93 (SNP -3156G > A) are significantl... Click to show full abstract

3574Background: Irinotecan is commonly used in the treatment of advanced colorectal and pancreatic cancer. The polymorphisms UGT1A1*28 (7 TA repeats) and UGT1A1*93 (SNP -3156G > A) are significantl...

Keywords: pharmacokinetic analysis; genotype guided; ugt1a1 genotype; safety pharmacokinetic; analysis ugt1a1; guided dosing

Journal Title: Journal of Clinical Oncology
Year Published: 2021

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