LAUSR

Abstract Heart failure is one of the most common causes of morbidity and mortality. Diabetes mellitus promotes the development of heart failure. Shortened sleep duration causes hormonal and metabolic changes and therefore can be a risk factor of heart failure. The aim of this pilot study was to define the link between the sleep duration and the risk of heart failure development . The study involved 217 patients but only 24 patients (5 male, 19 female) matched inclusion criteria. Self-reported sleep duration was obtained and brain natriuretic peptide (BNP) was measured in plasma using the chemiluminescent microparticle immunoassay (CMIA) ARCHITECT).The statistic relationship of BNP and sleep duration was assessed with test Cruscal-Wallis. The patients were divided into three groups: group «A» including 13 patients (2male), average age 56.9±2.1 with normal sleep duration about 7-9 hours, «B» including 2 (1 male) patients, average age 56.0± 9.0 with long sleep duration 9 hours and more and «C» including 9 patients ( 2 male),average age 62.0±2.1with shortened the sleep duration less 7 hours. Level of BNP obtained 49.7 ± 24.04(SD ±8.01) pg/ml, 17 ± 7.98 (SD ±2.21)pg/ml, 13.5 ± 4.94 (SD ± 3.5)pg/ml for groups A, B, C respectively. The duration of sleep in the group «С» was inversely proportional to the level of BNP in plasma and was significantly different from the group «А»( p = 0.003). Therefore the shortened sleep can be one of the additional risks of heart failure development.