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Granulomatous meningitis secondary to Avitene (microfibrillar collagen).

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Avitene, generically termed microfibrillar collagen, is a surgical hemostatic agent. Collagen-based hemostats are widely used to trigger platelet aggregation and reinforce the fibrin clot. Rarely, Avitene has been reported to… Click to show full abstract

Avitene, generically termed microfibrillar collagen, is a surgical hemostatic agent. Collagen-based hemostats are widely used to trigger platelet aggregation and reinforce the fibrin clot. Rarely, Avitene has been reported to induce a granulomatous reaction in the CNS, usually as a mass-forming lesion known as a textiloma. We report a case of Avitene-induced granulomatous inflammation presenting as meningitis after neurosurgery for WHO grade II atypical meningioma.

Keywords: collagen; microfibrillar collagen; meningitis secondary; avitene; granulomatous meningitis

Journal Title: Neurology: Clinical Practice
Year Published: 2017

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