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The protein product of the Drosophila additional sex combs-like (Asx) gene was shown to be a regulator, both a suppressor and an activator, of Hox developmental genes. Mammals, including humans,… Click to show full abstract
The protein product of the Drosophila additional sex combs-like (Asx) gene was shown to be a regulator, both a suppressor and an activator, of Hox developmental genes. Mammals, including humans, possess 3 Asx orthologs: 2 expressed ubiquitously, while the third, ASXL3, is predominantly expressed in the brain. All 3 are involved in transcriptional regulation of many genes through direct actions or epigenetically via histone modifications. Specific genes regulated by ASXL3 have not been identified.1,2
Keywords:
bainbridge ropers;
athetosis asxl3;
deficiency bainbridge;
ropers syndrome;
hyperventilation athetosis;
asxl3 deficiency
Journal Title: Neurology: Genetics
Year Published: 2017
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Journal Title: Neurology: Genetics
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!