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A 2-year-old boy with grade IV neuroblastoma presented with acute neurogenic bladder and hyposthenia after 2 weeks of treatment with anti-ganglioside-GD2 antibody (GD2-Ab). Spinal MRI findings are shown in the… Click to show full abstract
A 2-year-old boy with grade IV neuroblastoma presented with acute neurogenic bladder and hyposthenia after 2 weeks of treatment with anti-ganglioside-GD2 antibody (GD2-Ab). Spinal MRI findings are shown in the figure. On nerve conduction studies, there was sensorimotor demyelinating polyneuropathy with secondary axonal features, without conduction block. CSF examination revealed albuminocytologic dissociation. Sensorimotor polyneuropathy is a potential neurotoxic effect of anti-GD2-Ab.1 Spinal nerves contrast enhancement might be related to the binding of anti-GD2-Ab to spinal nerves myelin, determining active myelin breakdown. Anti-GD2-Ab toxicity should be included in the differential diagnosis of spinal nerve root contrast enhancement in children.2
Journal Title: Neurology
Year Published: 2018
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