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In 2014, a novel tauopathy characterized by REM sleep behavior disorder (RBD), sleep apnea, and stridor was first reported.1 Association with serum and CSF antibodies against IgLON5, a neuronal cell… Click to show full abstract
In 2014, a novel tauopathy characterized by REM sleep behavior disorder (RBD), sleep apnea, and stridor was first reported.1 Association with serum and CSF antibodies against IgLON5, a neuronal cell adhesion molecule of unknown function, was found in all patients.1 Neuropathologic examinations revealed neuronal accumulation of hyperphosphorylated 3-repeat (3R) and 4-repeat (4R) tau deposits in the hypothalamus and tegmental brainstem nuclei as the most relevant finding in the absence of inflammatory changes.2
Keywords:
cerebellar tau;
tau;
iglon5 case;
tau deposits;
case predominant;
predominant cerebellar
Journal Title: Neurology
Year Published: 2018
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Journal Title: Neurology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!