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Teaching NeuroImage: Non–24-Hour Sleep-Wake Rhythm Disorder

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A 77-year-old woman with obstructive sleep apnea reported a lifelong difficulty with periods of severe nocturnal insomnia and daytime sleepiness. Wrist actigraphy, the diagnostic method of choice for circadian rhythm… Click to show full abstract

A 77-year-old woman with obstructive sleep apnea reported a lifelong difficulty with periods of severe nocturnal insomnia and daytime sleepiness. Wrist actigraphy, the diagnostic method of choice for circadian rhythm disorders, was not covered by insurance. A review of her CPAP data (Figure) demonstrated progressively later bedtimes with a period of greater than 24 hours, revealing the diagnosis of non–24-hour sleep-wake rhythm disorder. While common in unsighted individuals, non–24-hour sleep-wake rhythm disorder can occur in sighted people,1,2 as was the case here. For patients on PAP therapy, adherence data can provide evidence of circadian rhythm disorders.

Keywords: sleep wake; hour sleep; wake rhythm; non hour; rhythm; rhythm disorder

Journal Title: Neurology
Year Published: 2022

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