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A 26-year-old woman presented with dizziness for 4 weeks, accompanied by vertigo and imbalance for 10 days. Physical examination revealed dysarthria, nystagmus, tremor, and severe ataxia. Infectious and malignant etiologies… Click to show full abstract
A 26-year-old woman presented with dizziness for 4 weeks, accompanied by vertigo and imbalance for 10 days. Physical examination revealed dysarthria, nystagmus, tremor, and severe ataxia. Infectious and malignant etiologies were excluded. High-titer anti-Homer-3 antibodies were detected in CSF and serum. Neuroimaging showed prominent cerebellar swelling with enhancement (Figure). She got limited improvement despite aggressive immunosuppression. MRI at 2-month follow-up showed cerebellar atrophy, suggesting unfavorable prognosis.
Journal Title: Neurology
Year Published: 2022
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