LAUSR

We are thankful for the interest and comments on our case report.1 Indeed, the longitudinally transverse myelopathy and the history of optic neuropathy in the present case might lead to a clinical suspicion of neuromyelitis optic spectrum disorders (NMOSDs) or other inflammatory demyelinating diseases. Although the negative serum AQP4-IgG and MOG-IgG antibodies could not deny the diagnosis of NMO/NMOSD, the large maternally inherited pedigree of genetically confirmed optic neuropathy highly suggested a multiorgan-involved mitochondrial disease rather than a coincidence of 2 separate diseases (LHON and NMOSD).2 Zalewski et al.3 reported that a significant MRI enhancement of the anterior gray matter was not uncommon and could even be observed in 39% of spinal cord infarctions.