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Author Response: Effectiveness of Antiseizure Medication Duotherapies in Patients With Glioma: A Multicenter Observational Cohort Study

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We appreciate the comments from Zhao et al. on our article.1 We agree that it is important to classify patients according to the latest World Health Organization (WHO) classification criteria… Click to show full abstract

We appreciate the comments from Zhao et al. on our article.1 We agree that it is important to classify patients according to the latest World Health Organization (WHO) classification criteria for CNS tumors to best inform current clinical decision-making. In our study, data were collected from patients with glioma treated between 2004 and 2018; therefore, patients were classified according to the 2016 WHO criteria. Nevertheless, we do not believe that reclassifying the patients in our cohort according to the 2021 WHO guidelines would affect our results regarding seizure outcomes because the change would only concern a small proportion of the patients and there is no available evidence that the antiseizure medications would have a different efficacy in patients with low-grade vs high-grade glioma with epilepsy.2

Keywords: antiseizure; response effectiveness; cohort; author response; study; patients glioma

Journal Title: Neurology
Year Published: 2023

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