LAUSR

In the research article entitled “Association of Diabetes and Hypertension With Brain Structural Integrity and Cognition in the Boston Puerto Rican Health Study Cohort,” Guan et al. reported that comorbid diabetes and hypertension is associated with a greater degree of brain structural disruptions than hypertension alone. Kawada commented that comorbid diabetes and hypertension was not associated with a greater degree of structural or functional impairment than diabetes or hypertension alone in a study by Newby et al. Koo and Guan responded that the relationship between diabetes and hypertension and brain structural integrity and cognition may vary across cohorts due to modification by social determinants of health. Kawada also noted that there is a bidirectional relationship between diabetes and dementia that should be considered when interpreting results of the study conducted by Guan et al., to which Koo and Guan replied that while they do not have data on β-amyloid and dementia for this cohort, this could be a future research direction.