LAUSR

In “Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis: A Retrospective Cohort Study,” Taquet et al. reviewed electronic health records and identified 2 cohorts of 152,754 people with coronavirus disease 2019 (COVID-19) or influenza and found a higher incidence of seizures and epilepsy in people with COVID-19 (hazard ratio 1.55 [1.39–1.74] and 1.87 [1.54–2.28], respectively, compared with influenza). Brenner postulated that this may be related to the effect of severe acute respiratory syndrome coronavirus 2 spike protein on release of synaptic vesicle protein 2A, a binding site for levetiracetam on neurons. Lin et al. noted that it is important to recognize the limitations of this study, including (1) potential survival bias in studying nonhospitalized patients, (2) the effect of vaccinations, and (3) the lack of data on seizure or epilepsy severity.