LAUSR

Well-differentiated liposarcoma (WDLPS) is the most common subtype of soft tissue sarcoma occurring in the retroperitoneum. Although complete macroscopic resection is the only potentially curative treatment, locoregional recurrences are common and occur in up to 60% of patients. Routine surveillance is the standard-of-care to detect disease recurrence across all cancer-types. Contemporary surveillance practices for WDLPS are directed by society guidelines, such as those published by the National Comprehensive Cancer Network, the European Society of Medical Oncology, and the Transatlantic Australasian Retroperitoneal Sarcoma Working Group, and generally recommend CT imaging every 3–6 months for the first 2 years but lack high-quality supporting evidence. As Sir Murray Brennan expressed 20 years ago, it remains unknown whether earlier detection improves sarcoma-specific outcomes, because it relies on the assumptions that (1) earlier recurrence detection results in better outcomes, and (2) effective treatments for recurrence are available once detected; neither of which have strong supporting evidence. PRESENT