LAUSR

Background The traditional Billroth II and Roux-en-Y anastomosis after laparoscopic distal gastrectomy for gastric cancer are associated with bile reflux gastritis and roux stasis syndrome, respectively. The uncut Roux-en-Y gastrojejunostomy can decrease the incidence of these complications by blocking the entry of bile and pancreatic juice into the residual stomach and retaining the impulses originating from the duodenum. The purpose of the present study was to compare the short-term outcomes of uncut Roux-en-Y (URY) and Billroth II combined Braun (BB) anastomosis. Methods In this prospective, multi-center, two-arm randomized controlled trial, 124 patients with advanced distal gastric cancer were randomized into two groups: URY ( n  = 62) and BB ( n  = 62) groups. Results The mean gastric juice pH was significantly lower in the URY group compared with the BB group (3.94 ± 0.71 vs. 5.83 ± 0.91, P  < 0.0001). The bile reflux gastritis at 3 months ( P  < 0.0001) and 6 months ( P  = 0.002) was significantly more frequent in the BB group. No recanalization occurred in the URY group, and no significant difference was found between the two groups in terms of mean operative time ( P  = 0.69), mean time to perform anastomosis ( P  = 0.86), mean estimated blood loss ( P  = 0.77), mean number of harvested lymph nodes ( P  = 0.90), time to first passage of flatus or defecation ( P  = 0.87), postoperative hospital stay ( P  = 0.83), and the incidence of postoperative complications ( P  = 0.70). Conclusions URY anastomosis is associated with a significantly lower incidence of bile reflux gastritis and roux stasis syndrome compared with BB anastomosis.