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ASO Author Reflections: Predicting Postoperative Resolution of Hypertension in Primary Hyperaldosteronism

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While hypokalemia routinely normalizes after unilateral adrenalectomy for primary hyperaldosteronism (PA), only one-third of patients will achieve postoperative normotension, and our ability to preoperatively identify those who will become normotensive… Click to show full abstract

While hypokalemia routinely normalizes after unilateral adrenalectomy for primary hyperaldosteronism (PA), only one-third of patients will achieve postoperative normotension, and our ability to preoperatively identify those who will become normotensive remains both a priority and a point of much contention. Clinical nomograms such as the Aldosterone Resolution Score (ARS) or the Primary Aldosteronism Surgical Outcome (PASO) score have demonstrated 75–80% accuracy in predicting complete clinical cure of hypertension (ccHTN), while adrenal venous sampling (AVS) provides biochemical confirmation of unilateral disease, thereby identifying patients who are likely to respond to adrenalectomy. To date, there has been limited conjunctive study of clinical and biochemical prognosticators.

Keywords: resolution; hyperaldosteronism; author reflections; primary hyperaldosteronism; aso author; hypertension

Journal Title: Annals of Surgical Oncology
Year Published: 2021

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