This study was the first to formally evaluate the conversion of low-grade appendiceal neoplasm to high-grade neoplasms following repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRSHIPEC). The focus of the… Click to show full abstract
This study was the first to formally evaluate the conversion of low-grade appendiceal neoplasm to high-grade neoplasms following repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRSHIPEC). The focus of the analysis is not a novel finding; conversion from low-grade to high-grade disease is a wellknown phenomenon for patients undergoing repeat CRSHIPEC. However, what is unknown is how often conversion occurs, how disease progression impacts clinical outcomes, and whether conversion presents a contraindication to repeat CRS-HIPEC. Furthermore, this study explored what could be potential risk factors for conversion to high-grade disease.
               
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