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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Although surgery is the mainstay of therapy, up to 80% of patients relapse after curative resection, suggesting the presence… Click to show full abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Although surgery is the mainstay of therapy, up to 80% of patients relapse after curative resection, suggesting the presence of systemic diffusion in the early phases of the disease. Several clinical trials have evaluated a preoperative therapeutic strategy, demonstrating that neoadjuvant chemotherapy (NACT) has a positive impact on patient outcomes compared with upfront surgery followed by adjuvant chemotherapy. NACT is known to induce a spectrum of histological changes in PDAC. Many tumor regression grading (TRG) systems have been developed, however they lack precision and accuracy, questioning their clinical utility. In this study, we sought to identify objective morphological parameters that portend prognostic value in PDAC patients resected after NACT to develop a prognostic index.
Journal Title: Annals of Surgical Oncology
Year Published: 2022
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