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Development of Off-On Switching 19F MRI Probes for Cathepsin K Activity Detection

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Cathepsin K is a protease expressed in osteoclasts that degrades bone tissue, such as type I collagen fibers. Overexpression of cathepsin K is involved in osteoporosis, rheumatoid arthritis, and bo... Click to show full abstract

Cathepsin K is a protease expressed in osteoclasts that degrades bone tissue, such as type I collagen fibers. Overexpression of cathepsin K is involved in osteoporosis, rheumatoid arthritis, and bo...

Keywords: development switching; 19f mri; probes cathepsin; mri probes; switching 19f; cathepsin activity

Journal Title: Bulletin of the Chemical Society of Japan
Year Published: 2021

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