LAUSR

For the synthesis of Gonytolide C, an enantioselective intramolecular allylic C–H oxidation was applied to afford the chiral chroman framework in good yield and enantioselectivity, and the key step to obtain the lactone moiety was a cascade dihydroxylation/intramolecular lactonization/elimination. This synthesis provides not only a novel synthetic approach to gonytolide C and its epimer, but also a valuable foundation for the asymmetric synthesis of gonytolides A–B.