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Copper-mediated Decarboxylative Coupling of Benzamides with Potassium Malonate Monoesters via Directed C–H Cleavage

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A copper-mediated decarboxylative coupling of benzamides with potassium malonate monoesters via 8-aminoquinoline-directed C-H cleavage has been developed. This reaction proceeds only by a copper salt to produce the corresponding alkylation… Click to show full abstract

A copper-mediated decarboxylative coupling of benzamides with potassium malonate monoesters via 8-aminoquinoline-directed C-H cleavage has been developed. This reaction proceeds only by a copper salt to produce the corresponding alkylation products in good yields.

Keywords: benzamides potassium; coupling benzamides; mediated decarboxylative; copper mediated; decarboxylative coupling; potassium malonate

Journal Title: Chemistry Letters
Year Published: 2018

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