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One-step Synthesis of 2-Hydroxy-2-(trifluoromethyl)malonates by Trifluoromethylation of 2-Oxomalonates with Ruppert-Prakash Reagent

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The one-step synthesis of 2-hydroxy-2-(trifluoromethyl)malonates is described. The nucleophilic trifluoromethylation of commercially available 2-oxo-malonates was possible by use of the Ruppert-Pra... Click to show full abstract

The one-step synthesis of 2-hydroxy-2-(trifluoromethyl)malonates is described. The nucleophilic trifluoromethylation of commercially available 2-oxo-malonates was possible by use of the Ruppert-Pra...

Keywords: trifluoromethyl malonates; step synthesis; synthesis hydroxy; one step; hydroxy trifluoromethyl

Journal Title: Chemistry Letters
Year Published: 2020

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