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Long INterspersed Element 1 (L1) is a mobile genetic element that is involved with muscle aging. However, exercise can downregulate this mechanism. Retrotransposons are gene segments that proliferate in the… Click to show full abstract
Long INterspersed Element 1 (L1) is a mobile genetic element that is involved with muscle aging. However, exercise can downregulate this mechanism. Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1 or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression influences muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.
Journal Title: Exercise and Sport Sciences Reviews
Year Published: 2022
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