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Future directions for medicinal chemistry in the field of oligonucleotide therapeutics

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In the last decade, the field of oligonucleotide therapeutics has matured, with the regulatory approval of several single-stranded and double-stranded RNA drugs. In this Perspective, I discuss enabling developments and… Click to show full abstract

In the last decade, the field of oligonucleotide therapeutics has matured, with the regulatory approval of several single-stranded and double-stranded RNA drugs. In this Perspective, I discuss enabling developments and likely future directions in the field from the perspective of oligonucleotide chemistry.

Keywords: chemistry; field oligonucleotide; future directions; directions medicinal; oligonucleotide therapeutics; field

Journal Title: RNA
Year Published: 2023

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