LAUSR

Background: Novel coronavirus disease has been recently a concern for worldwide public health. To determine epidemic rate probability at any time in any region of interest, one needs efficient bio-system reliability approach, particularly suitable for multi-regional environmental and health systems, observed over a sufficient period of time, resulting in a reliable long-term forecast of novel coronavirus infection rate. Traditional statistical methods dealing with temporal observations of multi-regional processes do not have the multi-dimensionality advantage, that suggested methodology offers, namely dealing efficiently with multiple regions at the same time and accounting for cross-correlations between different regional observations. Methods: Modern multi-dimensional novel statistical method was directly applied to raw clinical data, able to deal with territorial mapping. Novel reliability method based on statistical extreme value theory has been suggested to deal with challenging epidemic forecast. Authors used MATLAB optimization software. Results: This paper described a novel bio-system reliability approach, particularly suitable for multi-country environmental and health systems, observed over a sufficient period of time, resulting in a reliable long-term forecast of extreme novel coronavirus death rate probability.  Namely, accurate maximum recorded patient numbers are predicted for the years to come for the analyzed provinces. Conclusions:  The suggested method performed well by supplying not only an estimate but 95% confidence interval as well.  Note that suggested methodology is not limited to any specific epidemics or any specific terrain, namely its truly general. The only assumption and limitation is bio-system stationarity, alternatively trend analysis should be performed first.  The suggested methodology can be used in various public health applications, based on their clinical survey data.