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Targeting viral entry as a strategy for broad-spectrum antivirals

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The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our… Click to show full abstract

The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.

Keywords: entry strategy; targeting viral; entry; broad spectrum; viral entry

Journal Title: F1000Research
Year Published: 2019

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