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Response to “Comment on ‘Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors’”

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We and our recent analysis of the U.S. Environmental Agency ’ s (EPA) data from the high-throughput (HT) H295R screening of 656 chemicals in concentration-response. 1 We considered these same… Click to show full abstract

We and our recent analysis of the U.S. Environmental Agency ’ s (EPA) data from the high-throughput (HT) H295R screening of 656 chemicals in concentration-response. 1 We considered these same points as we conducted our initial work and further analyzed this issue (complete details are available at SilentSpringInstitute/E2upP4up_followup_Burgoon). We disagree with their assertion that the 296 chemicals we found to increase estradiol (E2) and progesterone (P4) in the HT-H295R assay are mostly false positives.

Keywords: estradiol progesterone; response comment; increase estradiol

Journal Title: Environmental Health Perspectives
Year Published: 2022

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