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The halogenated solvents trichloroethylene (TCE) and perchloroethylene (PCE; also called tetrachloroethylene) are high priorities for study owing to their adverse human health e ff ects. Certain key facts regarding TCE… Click to show full abstract
The halogenated solvents trichloroethylene (TCE) and perchloroethylene (PCE; also called tetrachloroethylene) are high priorities for study owing to their adverse human health e ff ects. Certain key facts regarding TCE and PCE toxicity and metabolism are well established and have not been in dispute; these include the widespread presence of these solvents in ground- and drinking water, 1 – 3 the classi fi cation of TCE as a known human carcinogen with the kidney and liver as primary targets, 1,2,4 the classi fi cation of PCE as a probable human carcinogen with the strongest evidence for bladder cancer, 1,3,5 and the prominent role of cytochrome P450s (CYPs) in mediating oxidative metabolism in both chemicals. 6 – 9 However, uncertainty remains regarding both the activity and the toxicological importance of glutathione (GSH) conjugation of TCE and PCE in the liver and kidney in humans and rodents. Although the kidney
Journal Title: Environmental Health Perspectives
Year Published: 2022
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