LAUSR

Atmospheric PM2.5 exposure is associated with respiratory diseases,and a high-fat diet is also one of the triggers of asthma.In recent years,the prevalence of asthma has been on the rise in China.Discussion on the effects of atmospheric PM2.5,high-fat diet,and their synergistic effects on the prevalence of asthma may provide a new ideas for the interventional treatment of asthma.The present study summarized the effects of PM2.5 exposure and high-fat diet on asthma and the pathogenesis of asthma,and pointed out:(1)The particulate matter exposure can trigger the inflammatory response in the body and increase the risk of asthma.(2)A high-fat diet can cause inflammation through metabolic activation of immune-related signaling pathways in the body.(3)Both can affect asthma inflammation through the MyD88/ TLRs signaling pathway and Th1 /Th2.The study reveals:the mechanism of action of PM2.5 and high-fat diet on asthma is consistent,which may have a synergistic effect on human health.