LAUSR

This study examined anterior corneal, internal ocular, and total ocular higher order aberrations (HOA's), and retinal image quality in a non-myopic, paediatric cohort. Anterior corneal aberrations were derived from corneal topography data captured using a Placido disk videokeratoscope (E300, Medmont International), and whole eye HOA's were measured using a Hartmann-Shack wavefront sensor (COAS-HD, Wavefront Sciences). The associations between HOA's and age, sex, refractive error, and axial length were explored using correlation analyses. Data for 84 children aged between 5 and 12 years (mean ± standard deviation spherical equivalent refraction (SER), +0.63 ± 0.35 D; range 0.00 to +1.75 D) were included, and an eighth order Zernike polynomial was fit for 4 and 6 mm pupil diameters for both the anterior corneal and total ocular HOA's, from which internal ocular HOA's were calculated via subtraction following alignment to a common reference axis (pupil centre). Internal ocular HOA's were of greater magnitude than previous studies of adolescents and adults, however partial internal "compensation" of HOA's was observed, which resulted in reduced levels of HOA's and excellent retinal image quality. Few significant associations were observed between HOA's and age, SER, and axial length (all correlations, p > 0.001), and there were minimal sex-based differences (all comparisons, p > 0.005). Coefficients for vertical coma ( C 3 - 1 and C 5 - 1 ) and spherical aberration ( C 4 0 and C 6 0 ), were most strongly associated with the visual Strehl ratio based on the optical transfer function (VSOTF), which indicated that the absolute magnitudes of these Zernike coefficients have the greatest impact on retinal image quality in this paediatric cohort. These findings provide an improved understanding of the optics and retinal image quality of children's eyes.