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Optical Probing of Hippocampal Function in a Mouse Model of Demyelination/Remyelination

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Nonlinear microscopy of calcium sensors was used to record hippocampal activity during induced demyelination and remyelination of axons for 100 days. Substantial changes to firing rates were identified during demyelination… Click to show full abstract

Nonlinear microscopy of calcium sensors was used to record hippocampal activity during induced demyelination and remyelination of axons for 100 days. Substantial changes to firing rates were identified during demyelination with partial recovery upon remyelination.

Keywords: demyelination; remyelination; optical probing; probing hippocampal; hippocampal function; demyelination remyelination

Journal Title: Brain
Year Published: 2020

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