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An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis

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The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of… Click to show full abstract

The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation and divergence of gasdermin E.

Keywords: gasdermin; conservation; mechanism conservation; defense mechanism; ancient defense; biology

Journal Title: PLOS Biology
Year Published: 2023

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