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Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

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The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid… Click to show full abstract

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

Keywords: overcoming biological; delivery; nucleic acid; biological barriers; acid delivery; lipid nanoparticles

Journal Title: PLOS Biology
Year Published: 2023

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