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Introduction AU : Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly: Gender differe ces have been around for many decades. In consequence, women demanded equal rights, achieving changes in education and publications of their works through revolutionary and social movements [1]. However, there is still evidence of gaps, reflected in women’s underrepresentation in jobs, institutions, and education, so that gender inequality persists [2]. For example, according to the progress on the sustainable development goals (SDGs), with a gender snapshot worldwide for 2021, women hold just 28% of jobs in science, technology, engineering, and mathematics (STEM) [3]. Despite these obstacles, the research work from women in STEM has shaped the scientific understanding in many fields and continues to do so with present-day contributions such as the Coronavirus Disease 2019 (COVIDAU : Pleasenotethat}COVID 19}hasbeenfullyspelledoutas}CoronavirusDisease2019}atfirstmentioninthesentence}Despitetheseobstacles; theresearchworkfromwomeninSTEM:::}Pleasecorrectifnecessary: -19) vaccin designed by Sarah Gilbert [4] or the genome editing technique by Jennifer Doudna and Emmanuelle Charpentier [5]. Likewise, achievements in geometric partial differential equations by Karen Keskulla Uhlenbeck, who was the first woman to win the Abel Prize for Mathematics in 2019 [6], or the discovery of a supermassive compact object at the galactic center by Andrea Chez can be mentioned [7]. In addition to these recognized women, many more continue to work for the benefit of science, inspiring girls worldwide. For example, Ecuadorian girls have sent letters to scientific women expressing their love for science (Figs 1 and 2). Despite these significant contributions, women still receive less recognition and awards. A total of 616 Nobel Prizes were awarded between 1901 and 2019 in Physics, Science, Medicine, and Physiology; however, only 19 were awarded to women. While some changes have been accomplished to reduce women’s underrepresentation in STEM, gender bias still exists nowadays. Consequently, this article poses ten simple rules on how society could change and prevent gender differences to empower women in STEM.