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Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the… Click to show full abstract
Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C
Keywords:
mismatch repair;
cancer;
crc;
colorectal cancer;
rhesus;
repair deficient
Journal Title: PLoS genetics
Year Published: 2022
Link to full text (if available)
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Journal Title: PLoS genetics
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!