LAUSR

Accumulation of carbonaceous particulate matter (PM) in the lung is associated with chronic disease. The amount of carbonaceous PM in airway macrophages is reported to be associated with exposure to both fossil fuel PM and cigarette smoke. However, the contribution of these exposures to carbonaceous PM at the lung surface is unclear. Objectives We therefore sought to identify the exposures associated with lung surface in long-term residents of São Paulo, Brazil. Methods Lung surface carbon were analyzed in 72 autopsy specimens by image analysis. Smoking history, measured PM10 nearest to the home, distance to main road, and distance-weighted traffic density were used as exposure variables. Data are summarized as median (IQR), and compared by Mann Whitney Test, with correlations done by Spearman’s correlation. Results There was no association between lung surface and age or gender. There was no statistically significant association in lung surface between smokers and non-smokers 6.74 cm2 (3.47 to 10.02) versus 5.20cm2 (2.29 to 7.54), and there was no significant association between lung surface carbon and exposure to environmental PM and markers of traffic exposure. Conclusion We did not find a statistically significant association between lung surface and smokers and non-smokers, and no statistically significant association between lung surface carbon and environmental exposure variables. These results suggest that lung surface carbon in long-term residents of São Paulo may predominately be from environmental PM, but the most appropriate environmental exposure marker remains unclear.