LAUSR

Cell wall architecture The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of the cell wall and appear perpendicular to the cell surface forming a fibrillar protein coat (Fig 1A). The polysaccharide rich inner layer is mainly made up of β-1,6and β-1,3-glucans and chitin while β-1,3-glucans and chitin are the structural polysaccharides in the cell wall. The development of antifungal therapies that target the cell wall has received great attention (Fig 1A) but with only limited success. The only cell wall-targeting antifungal agents, licenced for human infections, are echinocandins.