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PGRS domain structures: Doomed to sail the mycomembrane

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The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose… Click to show full abstract

The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS “sailing” model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.

Keywords: pgrs domain; doomed sail; mycomembrane; domain structures; sail mycomembrane; structures doomed

Journal Title: PLoS Pathogens
Year Published: 2022

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