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BACKGROUND We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI non-responsive (PPI-NR) EoE, and healthy controls. METHODS Transcript expression in mid-esophagus… Click to show full abstract
BACKGROUND We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI non-responsive (PPI-NR) EoE, and healthy controls. METHODS Transcript expression in mid-esophagus biopsies was determined using Nanostring and a custom panel of EoE-specific genes. The top up/downregulated genes with ≥2-fold difference in expression and statistically significant (P<0.05) were identified. RESULTS Nearly all of the top upregulated (17 out of 20) and downregulated (5 out of 5) genes in EoE, compared to healthy controls, were shared between the PPI-R and PPI-NR groups. CONCLUSION Esophageal mucosal transcript expressions are remarkably similar in PPI-R and PPI-NR EoE compared to healthy controls.
Journal Title: Clinical and translational gastroenterology
Year Published: 2022
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